Low-dose tablet formulations were produced with excellent homogeneity based on\ndrug-loaded electrospun fibers prepared by single-needle as well as scaled-up electrospinning\n(SNES and HSES). Carvedilol (CAR), a BCS II class compound, served as the model drug while\npoly (vinylpyrrolidone-co-vinyl acetate) (PVPVA64) was adopted as the fiber-forming polymer.\nScanning electron microscopy (SEM) imaging was used to study the morphology of HSES and SNES\nsamples. Different homogenization techniques were compared to maximize homogeneity: mixing\nin plastic bags and in a high-shear granulator resulting in low-shear mixing (LSM) and high-shear\nmixing (HSM). Drug content and homogeneity of the tablets were measured by UV-Vis spectrometry,\nthe results revealed acceptably low-dose fluctuations especially with formulations homogenized with\nHSM. Sieve analysis was used on the final LSM and HSM powder mixtures in order to elucidate the\nobserved differences between tablet homogeneity. Tablets containing drug-loaded electrospun fibers\nwere also studied by Raman mapping demonstrating evenly distributed CAR within the corpus.
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