Nanocrystallization and amorphization have proven to be two effective strategies to improve\nthe bioavailability ofwater-insoluble drugs. The purpose of ourworkwas to develop a nano-formulated\ntablet of sirolimus (SRL) for enhanced dissolution. Amorphous SRL nanocomposites were prepared\nusing anti-solvent precipitation via a high-gravity rotating packed bed. Various factors that affect\nparticle size and size distribution, such as excipients, rotating speed, antisolvent/solvent flow rate,\nwere investigated. Structure, stability and in vitro dissolution of the as-prepared SRL were evaluated.\nFurthermore, the nanoparticulated SRL tablet formulawas screened to control drug release. Importantly,\nSRL tablets exhibit different dissolution profile by adjusting HPMC (hydroxypropyl methyl cellulose)\ncontent, which makes them more suitable for various formulation developments.
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