Tobramycin is a potent antimicrobial aminoglycoside and its effective delivery by encapsulation\nwithin nanoparticle carriers could increase its activity against infections through a combination of\nsustained release and enhanced uptake. Effective antimicrobial therapy against a clinically relevant\nmodel bacteria (Pseudomonas aeruginosa) requires sufficient levels of therapeutic drug to maintain a drug\nconcentration above the microbial inhibitory concentration (MIC) of the bacteria. Previous studies have\nshown that loading of aminoglycoside drugs in poly(lactic-co-glycolic) acid (PLGA)-based delivery\nsystems is generally poor due to weak interactions between the drug and the polymer. The formation of\ncomplexes of tobramycin with dioctylsulfosuccinate (AOT) allows the effective loading of the drug in\nPLGA-nanoparticles and such nanoparticles can effectively deliver the antimicrobial aminoglycoside\nwith retention of tobramycin antibacterial function.
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