Present study investigated most efficient technique for the development of atorvastatin calcium liposomes. Aorvastatin calcium is a HMG-Co reductase inhibitor widely used in the treatment or prevention of hypercholesterolemia, mixed hyperlipidemia, coronary heart disease or stroke. Our work is mainly focused on in-vitro studies of liposomal formulation encapsulated with atorvastatin calcium which may have high drug entrapment, effective vesicle size. Drug loaded liposomes were prepared by thin film hydration techniques using soya lecithin, cholesterol and surfactant in various molar ratios. Liposome was evaluated for vesicle size, entrapment efficiency, zeta potential and drug release parameters. Optimized batches of atorvastatin Ca liposomal formulations prepared by thin film hydration technique have shown drug release as 90.43% respectively.
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