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Inventi Impact: Pharm Tech

Articles

  • Inventi:ppt/31436/20
    Application of Boxâ??Behnken Design to Investigate the Effect of Process Parameters on the Microparticle Production of Ethenzamide Through the Rapid Expansion of the Supercritical Solutions Process
    Research 2020 : April - June
    Yung-Tai Hsu, Chie-Shaan Su

    In this study, the rapid expansion of the supercritical solutions (RESS) process was used\nto produce microparticles of a commonly used anti-inflammatory drug, ethenzamide. The effects\nof process parameters in RESS including the extraction temperature, pre-expansion temperature,\nand post-expansion temperature were investigated using the Boxâ??Behnken design. According to\nthe results of the analysis of variance (ANOVA), the effect of pre-expansion temperature is the most\nsignificant parameter on the mean size of RESS-produced ethenzamide. A higher pre-expansion\ntemperature benefits the production of smaller crystals.........................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Hsu, Yung-Tai, and Chie-Shaan Su. \"Application of Box -Behnken Design to Investigate\nthe Effect of Process Parameters on the Microparticle Production of Ethenzamide through the Rapid Expansion of the\nSupercritical Solutions Process.\" Pharmaceutics 12.1 (2020): 42.\nhttps://doi:10.3390/pharmaceutics12010042\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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