We have previously reported that heated powder mixtures of ibuprofen (IBU) and high\nsurface area nanocellulose exhibit an enhanced dissolution and solubility of the drug due to IBU\namorphization. The goal of the present work was to further elaborate the concept and conduct\nside-by-side in vitro drug release comparisons with commercial formulations, including film-coated\ntablets, soft gel liquid capsules, and IBU-lysine conjugate tablets, in biorelevant media. Directly\ncompressed tablets were produced from heated mixtures of 20% w/w IBU and high surface area\nCladophora cellulose (CLAD), with 5% w/w sodium croscarmelose (AcDiSol) as superdisintegrant.\nThe side-by side studies in simulated gastric fluid, fasted-state simulated intestinal fluid, and fed-state\nsimulated intestinal fluid corroborate that the IBU-CLAD tablets show more rapid and less variable\nrelease in various media compared to three commercial IBU formulations. On the sidelines of the\nmain work, a possibility of the presence of a new meta-crystalline form of IBU in mixture with\nnanocellulose is discussed.
Loading....