The major drawback of poorly water soluble drugs will be their therapeutic application and efficacy as an oral dosage form is their very low aqueous solubility because of their hydrophobic nature. An attempt to improve the solubility and therapeutic efficacy of an oral anti-diabetic (Nateglinide) by preparing inclusion complexes with �Ÿ-CD in various ratios (C1-1:1 Nateglinide: �Ÿ-CD, C2-1:2 Nateglinide: �Ÿ-CD, C3-1:3 Nateglinide: �Ÿ-CD) using Kneading method. Prepared inclusion complexes were evaluated by LC-MS, XRD, HPLC, DSC, HPTLC and NMR. After evaluations of all the prepared inclusion complexes were subjected to in-vivo study, among all prepared inclusion complex C1 showed the best release pattern.
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