Recent decades have seen tremendous strides in the designing of novel dosage forms, but tablets still remain an attractive option for pharmaceutical scientists and clinicians because they offer advantages of accurate unit-dosing, better patient compliance, ease of large-scale manufacturing, and low production cost. Tablet manufacturing has been changed by the introduction of the direct-compression process and high-speed machines. These two developments have increased the demands on the functionality of excipients in terms of flow and compression properties. Excipients combinations using co-processing, by virtue of sub-particle modifications, has provided an attractive tool for developing high functionality excipients that are suited to modern tablet manufacturing processes.
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