The major drawbacks associated with the conventional administration of ondansetron hydrochloride can be attenuated using the skin as a route of administration. However, the effective transdermal delivery is limited by the skin barrier properties. The main objective of the present work was the mechanistic investigation on penetration enhancing effect of different natural essential oils on the transdermal permeation of ondansetron hydrochloride using different analytical tools like scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and fourier transform infrared spectroscopy (FT-IR). The enhancing effects of citronella oil, lemon oil and nutmeg oil were investigated across enhancer pretreated pig skin in Keshary-Chien glass diffusion cell. The target flux of ondansetron hydrochloride was achieved with 15 % v/v lemon oil. The in vitro permeation data was best fitted with the zero order kinetic model indicating that the mechanism of drug permeation was diffusion controlled. The FT-IR, SEM and DSC study confirmed that the permeation enhancement effect of the investigated enhancers was caused by the stratum corneum lipid extraction mechanism. A higher enhancement value was observed with lemon oil followed by nutmeg oil and citronella oil.
Loading....