For the effective treatment of various skin and soft tissue diseases, cloxacillin medicated cream were prepared. The formulations were subjected to various physicochemical studies like pH, spreadability, extrudability, drug content, in vitro drug release, and stability studies. The preparations were non-Newtonian and exhibited pseudoplastic behavior. In vitro drug release studies were carried out using a pH 6 phosphate buffer as a receptor medium. Formulations exhibited an extended release of the drug for over a period of 3 hours and the release depended on the type of base used. Stability studies showed no significant variations (P > 0.05) in pH, spreadability, extrudability, and drug content. An in vitro release study concluded that oil-in-water cream based preparation appeared to probably extend the release of cloxacillin.
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