Fast dissolving tablets were dissolved/disintegrated in the mouth within a matter of few seconds without need of water. Fenofibrate is a fibric acid derivative drug of the fibrate class. It is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. It reduces both LDL and low VLDL levels and enhance the level of HDL levels .The purpose of this research was to develop fast dissolving tablets of fenofibrate were prepared by sublimation method and direct compression method. In the Sublimation method, different sublimating agent like camphor, thymol and menthol were used while in direct compression method Crosspovidone, KyronT314, Sodium Starch glycolate as superdisintegrating agents were used in different concentration. The prepared batches of tablets were evaluated for thickness, hardness, weigh variation, friability, drug content uniformity, wetting time, disintegration time and in-vitro dissolution study. From these, fenofibrate fast dissolving tablet prepared by sublimation method gives better release profile as well as wetting and disintegration time as compared to direct compression method. Optimized batch was F9 with 15 % menthol as a sublimating agent having better disintegration time (18 sec), wetting time (23 sec) and t90 % was 12 min.
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