The concept of mucoadhesion started in early 1980’s. Since, then much advancement took place in designing mucoadhesive drug delivery systems. These delivery systems make an intimate contact with mucosa of the respective site to enhance the drug absorption by sustaining or increasing the residence time of the drug at the respective site. In addition, the physicochemical properties of polymers investigated in designing various delivery systems viz., tablets, microcapsules, films, patches, gels, etc., has affected the process of mucoadhesion invariably. So for better understanding, the review focuses on the nature, theories and sites of mucoadhesion, polymers for mucoadhesion and delivery systems. In this connection, the review enlightens the current new generation polymers explored for mucoadhesion and outlines the research work carried out on this area.
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