Ginger (Zingiber officinale) has traditionally been used in delicacy, medicine, or spice. aromatic, pungent, spicy, has been claimed as an antioxidant and also an anti-ulcer agent; Evaluation of in vitro antioxidant activity of ginger extract (GE) in a series of in vitro test systems and its comparison with ascorbic acid showed promising data. In the present study we developed floating beads (FBs) of GE with intent to achieve a localized therapeutic action and a prolonged stay in the stomach. Developed beads were evaluated for ethanol induced gastric ulcers in rats. Latter is a model for oxidative stress induced gastric ulcers. Oxidative stress of the stomach mucosa in terms of malondialdehyde and antioxidant enzymatic parameters showed a significant attenuation with free GE which was further enhanced significantly by the developed FBs of GE. The number and severity of ulcers (ulcer index) significantly reduced by 48% at1 hours post administration with free GE, the value increased to 62.5% at 1 hour & further 83% at 24 hours post administration with developed floating beads of GE.
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