In the present study, solid dispersion (SD) of nitrendipine was prepared to enhance its water solubility. The SD was prepared by using poly-vinyl alcohol (PVA) and poloxamer188 (PXM188) as a carrier. The different drug polymer ratios were prepared by the techniques physical mixing and solvent evaporation. The product was characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD) and in vitro dissolution rate studies. Phase solubility analysis was performed in aqueous solution for drug polymer interactions. DSC and XRD analysis demonstrated the conversion of nitrendipine to amorphous form with both physical mixture (PM) and SD. SD with PXM188 released 98% of the drug in 100 min as compared with 79% of drug released in 100 min by SD with PVA. Thus, SD with both polymers increased drug release, particularly greater in the case of PXM188 than PVA.
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