The rate-limiting step to absorption of drugs from the gastrointestinal tract is often dissolution from the dosage form. Diacerein is used drug in the treatment of Osteoarthritis. One of the major problems with Diacerein is that, it is practically insoluble in water,coming under class-II of biological classification system,, which results in poor bioavailability after oral administration. In the present study, solid dispersions of Diacerein were prepared by solvent evaporation method, Physical mixture and Fusion method to increase its water solubility. In the present study amphiphilic carrier like gelucire 50/13 was used in the ratio of 1:1, 1:3 and 1:5. Prepared solid dispersions were characterized in the liquid state by phase solubility studies and in the solid state by Differential Scanning calorimetric analysis, Powder X-ray diffractometry,Scaning electron microscopy and Fourier Transform Infrared spectroscopy. The aqueous solubility of Diacerein was preferential by the presence polymer with increasing concentration. Solid state characterizations indicated that Diacerein was present as an amorphous material and entrapped in polymer matrix. The release study findings were well supported by the results of wettability, saturation solubility and permeability studies.
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