The purpose of this research works to develop and optimized the extended release film coated matrix tablet of Divalproex sodium to mask the foul taste of divalproex sodium, improve the product stability and to modulate the release properties. In the present study extended release tablet of Divalproex sodium was prepared by using wet granulation method. Different grades of hydroxypropyl methyl cellulose (K100M CR and HPMC K15M CR) were evaluated for gel forming properties. Preformulation study shows that drug and other excipients are compatible with each other. The tablets were made film coated by using specific coating polymer. The effects of polymers concentration on drug release profile were investigated. All the Prepared formulations were evaluated for the physical characteristics, in vitro dissolution and accelerated stability study was also performed for three months indicated that optimized formulation was stable. Finally, process optimization was carried out to optimize the process parameters like kneading time, mixing time, thickness of the tablet and lubrication time. The release of divalproex sodium from the film coated tablet for a period up to 18 hrs was recorded in controlled manner. \nKeywords: Extended release, epilepsy, Divalproex sodium, Matrix tablet, Kneading time.
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