The gliclazide microcapsules were formulated to extend the hypoglycemic effect for a period of 10-12hrs. The gliclazide microcapsules were formulated by using ionic gelation method with and without mechanical stirring. The effect of various process variables such as curing time, stirring speed, stirring time, volume of curing reagent and concentration of curing reagent on entrapment efficiency and drug release rate was studied. The optimized formulation was selected based on the entrapment efficiency and drug release rate. The optimized formulation of gliclazide microcapsules were subjected to the hypoglycemic activity in healthy albino rabbits (n=5). The blood glucose levels were measured and then percentage glucose reduction was calculated. The data was treated statistically. Compared the mean blood glucose levels observed from gliclazide and its microcapsules. The hypoglycemic activity of pure drug was observed at 2nd -3rd hour and it was extended for a period of 2nd to 10th hour in case of microcapsules.
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