In the present study, we formulated liposomes of salbutamol sulphate, antiasthamatic drug in order to improve pulmonary delivery by Thin Film Hydration technique, using lipid- Phospholipon�® 90G as a lipid of choice. Sustained release effect of liposomes was found to be extended as long as 10hrs and maximum drug entrapment was found to be 40-50%. Salbutamol sulphate, 0.1 % was incorporated in a ratio of 1:10 with that of lipid. To obtain rigidity and stability to liposomal vesicles, cholesterol and antioxidant Butylated Hydroxy Anisole (BHA) were used. 33 Factorial Design was applied to optimize concentration of cholesterol , BHA and PH of hydration buffer with respect to percentage drug entrapment. Stable liposomes were obtained with 0.25% of cholesterol and hydrating buffer pH, 6.4. In further process variables study, the maximum drug entrapment was found to be about 52-55% at the lowest rotation speed, 30rpm; and at optimum ratio of batch size to rotary flask capacity as 1:5.
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