The aim of present work is to develop floating osmotic tablet (FOT) for controlled release of losartan potassium that deliver drug at zero order over prolong period. The objective of investigation was to formulate a FOT for controlled release of losartan potassium which is useful for treatment of the hypertension by maintaining the plasma drug concentration above the minimum effective concentration. Tablet formulation was carried out by wet granulation technique and before that preformulation study of the drug was carried out. Various factor affect on drug release of losartan potassium from FOT, among them concentration of polymer, osmotic agent and sodium bicarbonate were selected as the independent variable for optimization of the formulation by box-behnken design. From in vitro dissolution and buoyancy study T50, Q12 and floating lag time were selected as the dependent variable (Y). By the help of DE® 9.0.1.0 software the optimized batch was found out. SEM study of the optimized batch was performed which showed the orifice size was around 500 μm. Release kinetic model were applied to the optimized batch which showed the formulation follow zero order drug release with anomalous transfer because R2 of zero order plot was 0.989 and n of korsmeyer peppas model was 0.862 which was less than 1. Stability study of optimized batch was performed at 40°C/ 75% RH up to 1 month and there was no stability problem reported.
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