Exposure to oxidant molecules from the environment (pollution, radiation or from within body fluids and tissues), dietary imbalances, malnutrition or pathologic conditions can generate ROS. The free radicals once generated can target proteins, lipids and DNA thus can cascade, initiating lipid peroxidation which results in destabilization and disintegration of the cell membranes or oxidation of other cellular components, finally resulting in the disruption of cells Depletion of cellular antioxidants in acute oxidative stress increases ROS accumulation, which in turn is responsible for several chronic pathologies. High fat-high cholesterol feeding resulted in significantly elevating the lipid and oxidative stress levels of blood and hepatic tissues of rats. However, concomitant feeding of neutraceuticals reduced the lipid levels and diminished the oxidative stress. Thus to prevent cellular damages associated with free radicals and oxidative stress, it is important to restore the balance of endogenous antioxidants through antioxidant supplementation.
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