Obesity is no longer a cosmetic issue but an epidemic that threatens global wellbeing. Sedentary lifestyle, eating high fat, energy dense food and drinks and several genetic factors had led severe prevalence of obesity worldwide. Recently calcium has been evolved with an antiobesity potential and probiotic are found to have their role in improving calcium absorption. Increase in body weight and fat was ensured by providing fructose as an obesogenic diet along with normal chow diet. Oyster shells are known to be rich source of calcium that has proven to be excellent ‘natural calcium supplement’. Shells were processed to obtain oyster shell powder (OSP). All rats except normal received fructose (30% w/v) along with their normal chow diet. Treatment groups received OSP (82 mg/kg or 55.4 mg/kg p.o.), or Probiotic (Lactobacillus acidophilus 109CFU/animal/day p.o.), or combination of OSP and Probiotic (i.e. 82 mg/kg and Lactobacillus acidophilus 109CFU/day, or 55.4 mg/kg and Lactobacillus acidophilus 109CFU/day orally). Biochemical parameters, anthropometric parameters, nutritional parameters were evaluated. Peritoneal and epididymal fat pad were analyzed for histopathological studies. Chronic supply of fructose decreased HDL levels whereas increased glucose, triglyceride, total cholesterol, anthropometric parameters, nutritional parameters, body weight gain, weight of fat pad and showed peritoneal and epididymal fat cell hypertrophy and hyperplasia. The treated groups showed significant restoration in these obesogenic parameters. The results have shown that OSP as well as combination of OSP and Probiotic have good potential in management of obesity.
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