Moringa oleifera is amultipurpose plant used in Ghana and most parts of Africa. Its high mineral, protein, and vitamins content has\nenabled its use as a nutraceutical and panacea for various diseases. This study aimed at measuring the micro- and macroelements\ncontent of dried Moringa oleifera leaves using energy dispersive X-ray fluorescence spectroscopic (EDXRF) and assessing its\ntoxicological effect in rats. Acute toxicity (5000mg/kg) and a subacute toxicity studies of the leaf (40mg/kg to 1000mg/kg) extract\nwere conducted in rats. Blood samples were assessed for biochemical and haematological parameters. Results showed significant\nlevels of thirty-five (35) elements (14 macroelements and 21 microelements) in M. oleifera extract. There were no observed overt\nadverse reactions in the acute and subacute studies. Although there were observed elevations in liver enzymes ALT and ALP\n(???? < 0.001) and lower creatinine levels in the extract treated groups, no adverse histopathological findings were found. Moringa\noleifera dried leaf extract may, therefore, be reasonably safe for consumption. However, the consumption of Moringa oleifera leaves\nshould not exceed a maximum of 70 grams per day to prevent cumulative toxicity of these essential elements over long periods.
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