Background: Overweight subjects easily develop alterations of the glucose and lipid metabolism and are exposed\nto an increased cardiometabolic risk. This condition is potentially reversible through the improvement of dietary\nand behavioural habits. However, a well-assembled nutraceutical would be a useful tool to better improve the\nmetabolic parameters associated to overweight and insulin resistance.\nMethods: To evaluate the effect of a combined nutraceutical containing berberine, chlorogenic acid and\ntocotrienols, we performed a double blind, cross-over designed trial versus placebo, in 40 overweight subjects\nwith mixed hyperlipidaemia. After the first 8 weeks of treatment (or placebo), patients were asked to observe a\n2-week washout period, and they were then assigned to the alternative treatment for a further period of 8 weeks.\nClinical and laboratory data associated to hyperlipidaemia and insulin resistance have been obtained at the\nbaseline, at the end of the first treatment period, after the washout, and again after the second treatment period.\nResults: Both groups experienced a significant improvement of anthropometric and biochemical parameters\nversus baseline. However, total cholesterol, LDL cholesterol, triglycerides, non-HDL cholesterol, fasting insulin,\nHOMA-IR, GOT and Lipid Accumulation Product decreased more significantly in the nutraceutical group versus\nplacebo.\nConclusions: This combination seems to improve a large number of metabolic and liver parameters on the\nshort-term in overweight subjects. Further studies are needed to confirm these observations on the middle- and\nlong-term.
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