There is a need for innovation in plant-derived pharmaceuticals, food supplements\nand nutraceutical products regarding the use of more eco-sustainable solvents for their extraction.\nFurthermore, the poor oral bioavailability of several phytochemicals with health promoting effects\nstimulates the research in the field of pharmaceutical formulations. Natural Deep Eutectic Solvents\n(NADES) are formed by natural compounds, and can be considered as future solvents being\nespecially useful for the preparation of nutraceuticals and food-grade extracts. In this paper\nvarious NADES were prepared using sugars, aminoacids and organic acids. Rutin (quercetin-3-O-\nÃ?±-L-rhamnopyranosyl-(1ââ? â??6))-Ã?²-D-glucopyranose) was used as a model compound to study\nNADES. Moreover, the effect of various eutectic mixtures on rutinââ?¬â?¢s water solubility was studied.\nProline/glutamic acid (2:1) and proline/choline chloride (1:1) mixtures have a solubility comparable\nto ethanol. The proline/glutamic acid (2:1) eutectic containing rutin was used in a pharmacokinetic\nstudy in Balb/c mice while bioavailability was compared to oral dosing of water suspension.\nPlasmatic levels of rutin were measured by HPLC-MS/MS showing increased levels and longer\nperiod of rutin permanence in plasma of NADES treated animals. This paper reports the possible use\nof non-toxic NADES for pharmaceutical and nutraceutical preparations.
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