Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with increased\nrisk for cardiovascular disease and overall mortality. Excessive alcohol intake is a well-known risk\nfactor for AF, but this correlation is less clear with light and moderate drinking. Besides, low doses of\nred wine may acutely prolong repolarization and slow cardiac conduction. Resveratrol, a bioactive\npolyphenol found in grapes and red wine, has been linked to antiarrhythmic properties and may\nact as an inhibitor of both intracellular calcium release and pathological signaling cascades in AF,\neliminating calcium overload and preserving the cardiomyocyte contractile function. However,\nthere are still no clinical trials at all that prove that resveratrol supplementation leads to improved\noutcomes. Besides, no observational study supports a beneficial effect of light or moderate alcohol\nintake and a lower risk of AF. The purpose of this review is to briefly describe possible beneficial\neffects of red wine and resveratrol in AF, and also present studies conducted in humans regarding\nchronic red wine consumption, resveratrol, and AF.
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