The aim of the present critical review is to summarize the available clinical evidence\nsupporting the use of some dietary supplements that have been shown to lower blood pressure in\nhypertensive pregnant women. A systematic search strategy was carried out to identify trials in\nMEDLINE (National Library of Medicine, Bethesda, Maryland, MD, USA; January 1980 to September\n2019) and the Cochrane Register of Controlled Trials (The Cochrane Collaboration, Oxford, UK). The\nterms â??nutraceuticalsâ??, â??dietary supplementsâ??, â??pregnancyâ??, â??pre-eclampsiaâ??, â??clinical trialâ??, and â??humanâ??\nwere incorporated into an electronic search strategy. The references of the identified studies and\nreview articles were reviewed to look for additional studies of interest. We preferably selected papers\nthat reported recent comprehensive reviews or meta-analysis, or original clinical trials of substances\nwith blood pressure-lowering or vascular protective effect in pregnancy. There is a relative body of\nevidence that supports the use of calcium, vitamin D, folic acid, and resveratrol in preventing the\ndevelopment of hypertensive disorders in pregnancy, and evidence supporting drug treatment too.\nFurther clinical research is advisable to identify the dosage and timing of the supplementation, the\ngroup of women that might benefit the most from this approach, and the nutraceuticals with the best\ncost-effectiveness and risk-benefit ratio for widespread use in clinical practice.
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