Liver protects the body from potentially injurious substances absorbed from intestinal tract as well as toxic by-products of the metabolism. The study was designed to evaluate the hepatoprotective activity of ethanolic extract of Zingiber officinale in acute experimental liver injury induced by Nitrobenzene in mice. The extract at the dose of 200 mg/kg BW was administered orally once every day for 30 days. The nitrobenzene induced mice (8µg/kg BW) significantly increased the levels of serum marker enzymes (aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) and lipidperoxidation (LPO) levels whereas on treatment with ethanolic extract of Zingiber officinale (200 mg/kg bw) restored towards normalization. The significantly decreased antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were increased after treatment. Histopathological analysis of nitrobenzene induced animal showed severe centrilobular necrosis, fatty infiltration and lymphocyte infiltration. After treatment with ethanolic extract of Zingiber officinale, all these factors were minimized which proved that this plant possess good hepatoprotective activity.
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