Background: Because the source of protein may play a role in its satiating effect, we investigated the effect of\r\ndifferent proteins on satiation and short-term satiety.\r\nMethods: Two randomized single-blind cross-over studies were completed. In the first study, we investigated the\r\neffect of a preload containing 20 g of casein, whey, pea protein, egg albumin or maltodextrin vs. water control on\r\nfood intake 30 min later in 32 male volunteers (25 �± 4 yrs, BMI 24 �± 0.4 kg/m2). Subjective appetite was assessed\r\nusing visual analogue scales at 10 min intervals after the preload. Capillary blood glucose was measured every 30\r\nmin during 2 hrs before and after the ad libitum meal. In the second study, we compared the effect of 20 g of\r\ncasein, pea protein or whey vs. water control on satiation in 32 male volunteers (25 �± 0.6 yrs, BMI 24 �± 0.5 kg/m2).\r\nThe preload was consumed as a starter during an ad libitum meal and food intake was measured. The preloads in\r\nboth studies were in the form of a beverage.\r\nResults: In the first study, food intake was significantly lower only after casein and pea protein compared to water\r\ncontrol (P = 0.02; 0.04 respectively). Caloric compensation was 110, 103, 62, 56 and 51% after casein, pea protein,\r\nwhey, albumin and maltodextrin, respectively. Feelings of satiety were significantly higher after casein and pea\r\nprotein compared to other preloads (P < 0.05). Blood glucose response to the meal was significantly lower when\r\nwhey protein was consumed as a preload compared to other groups (P < 0.001). In the second study, results\r\nshowed no difference between preloads on ad libitum intake. Total intake was significantly higher after caloric\r\npreloads compared to water control (P < 0.05).\r\nConclusion: Casein and pea protein showed a stronger effect on food intake compared to whey when consumed\r\nas a preload. However, consuming the protein preload as a starter of a meal decreased its impact on food intake\r\nas opposed to consuming it 30 min before the meal
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