The present study was to investigate the protecting or preventing effect of dehydrated leaves of Anethum sowa linn leaves extracts against the oxidative stress induced in rats by dimethyl hydrazine (DMH). In DMH administered rats, measurement of cytotoxicity was carried out by assaying lipid peroxidation product viz, MDA, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), Glutathione reductase (GSSGR), Glutathione S-transferase (GST) and Glutathione in rat liver. Effect of pre-feeding dehydrated drumstick (Anethum sowa) leaves at 10% levels on the above parameters was further evaluated. DMH induced significant rise in MDA with concomitant decrease in GSH. An increase in the hepatic GSH level was seen in rats fed with Anethum sowa. DMH influenced adversely the hepatic antioxidant enzymes viz, GSH-Px, CAT, SOD and GSSGR. Results suggest that consumption of Anethum sowa at 10% level prevent the oxidative stress caused by DMH in liver & erythrocytes.
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