Purpose. To review the proposed pathogenic mechanisms of age macular degeneration (AMD), as well as the role of antioxidants\r\n(AOX) and omega-3 fatty acids (??-3) supplements in AMD prevention. Materials and Methods. Current knowledge on the\r\ncellular/molecular mechanisms ofAMDand the epidemiologic/experimental studies on the effects of AOX and ??-3 were addressed\r\nall together with the scientific evidence and the personal opinion of professionals involved in the Retina Group of the OFTARED\r\n(Spain). Results. High dietary intakes of ??-3 and macular pigments lutein/zeaxanthin are associated with lower risk of prevalence\r\nand incidence in AMD. The Age-Related Eye Disease study (AREDS) showed a beneficial effect of high doses of vitamins C, E,\r\nbeta-carotene, and zinc/copper in reducing the rate of progression to advanced AMD in patients with intermediate AMD or with\r\none-sided lateAMD.The AREDS-2 study has shown that lutein and zeaxanthin may substitute beta-carotene because of its potential\r\nrelationship with increased lung cancer incidence. Conclusion. Research has proved that elder people with poor diets, especially\r\nwith low AOX and ??-3 micronutrients intake and subsequently having low plasmatic levels, are more prone to developing AMD.\r\nMicronutrient supplementation enhances antioxidant defense and healthy eyes and might prevent/retard/modify AMD.
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