Abstract\nBackground: The purpose of this study was to estimate the effects of a 3-year dietary intervention on age-related\nchanges in triglyceride and apolipoprotein (apo A-V) levels in patients with impaired fasting glucose (IFG) or\nnew-onset type 2 diabetes as a function of the APOA5 -1131 T > C polymorphism.\nMethods: We genotyped the APOA5 -1131 T > C polymorphism in 203 Korean individuals with IFG or new-onset\ntype 2 diabetes for the TT (n = 91), TC (n = 98), and CC (n = 14) alleles. Plasma apo A-V and triglyceride levels were\nevaluated at baseline and after a 3-year dietary intervention.\nResults: Our results showed that HDL, glucose, insulin, HOMA-IR index, free fatty acids, and apo A-V decreased and\nbrachial-ankle pulse wave velocity (ba-PWV) and malondialdehyde (MDA) increased at the 3-year follow-up visit\ncompared with baseline. Plasma apo A-V levels were reduced in subjects with the C allele (TC or CC) (P = 0.036) and\ntriglyceride levels were reduced in subjects with the TT allele (P = 0.047). Subjects with the C allele showed lower\npost-treatment apo A-V and higher post-treatment fasting triglyceride levels than subjects with the TT allele.\nChanges in apo A-V and triglyceride levels were negatively correlated in subjects with the TT allele and positively\ncorrelated in subjects with the C allele.\nConclusions: This study showed that the dietary intervention prevented an age-related increase in triglyceride\nlevels in individuals with IFG or new-onset type 2 diabetes who possess the TT allele, but not the CT or CC allele, of\nthe APOA5 -1131 T > C polymorphism.
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