Fumonisin B1 (FB1) is produced by fungus of the genus Fusarium (Fusarium verticiloides and F.\nproliferatum), and occurs predominantly in maize. The consumption of feed contaminated with\nFB1 has been reported to cause deleterious effects in some fish species. This study was designed to\ndetermine the effects of dietary FB1 on growth and lipids profile of Clarias gariepinus. 450 juvenile\ncatfish were stocked into 5 groups of tanks consisting of 3 tanks per group and fed one of five diets\namended with FB1 (0.0 mg; 10.0 mg; 20.0 mg; 40.0 mg and 80.0 mg FB1/kg) for 56 days. At time\npointâ��s day 7, 14, 28 and 56, five fish were sampled from each tank weighted, length measured and\nbled for of lipids profile determinations. Results show that there was a significant reduction (P <\n0.05), in the mean body length of the fish fed diets amended with various amounts of FB1 compared\nwith those fed control diet; also, there was a significant reduction (P < 0.05) in the weight\ngain of fishes fed diets amended with FB1 compared with the control. The specific growth rate and\nthe feed conversion ratio at 56 days shows fish fed 0.0 mg FB1/kg had the highest specific growth\nrate (0.39 �± 0.14%/day) and the lowest feed conversion ratio (0.59 �± 0.01) whereas, fish fed 80.0\nmg FB1/kg had the least specific growth rate (0.07% �± 0.01%/day) and the highest feed conversion\nratio (1.95 �± 0.11). Dietary FB1 caused significant increases (P < 0.05) in serum cholesterol,\nHDL-C; LDL-C; triglycerides and the sphinganine-sphingosine ratio. Dietary FB1 at an inclusion rate\n 20 mg FB1/kg of diet produced significant reduction in weight gain and hyperlipidemia marked by hypercholesterolemia, increased blood high-density lipid cholesterol, increased blood\nlow-density lipid cholesterol, elevated blood triglycerides and elevated sphinganine-sphingosine\nratio.
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