Platelet-rich plasma (PRP) preparations are used inhorseswith osteoarthritis (OA).However, some controversies remain regarding\nthe ideal concentration of platelets and leukocytes to produce an adequate anti-inflammatory and anabolic response in the synovial\nmembrane. The aims of this study were to study the influence of leukoconcentrated platelet-rich gel (Lc-PRG) and leukoreduced\nplatelet-rich gel (Lr-PRG) supernatants on the quantitative expression of some proinflammatory and anabolic genes in equine\nsynovial membrane explants (SMEs) challenged with lipopolysaccharide (LPS). SMEs from six horses were cultured over 96 h.\nThen, SMEs were harvested for RNA extraction and quantitative gene expression analysis by RT-qPCR for nuclear factor kappa B\n(NF
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