Background: Infectious canine hepatitis is a rarely encountered disease, that is caused by Canine Adenovirus-1.\nClinical signs can vary dramatically, and neurological signs are rarely seen. Neurological manifestation of this disease\nis rarely reported in the veterinary literature.\nCase presentation: A 5-week-old, male entire Husky cross puppy presented for a one-day history of abnormal\nneurological behaviour (circling, ataxia, vocalization and obtund mentation). The puppy was euthanized shortly after\npresentation due to rapid deterioration. Histopathology raised concerns for Canine Adenovirus 1 (CAdV-1) based on\nvasculitis in the brain and intranuclear inclusion bodies in endothelial cell and hepatocytes; immunohistochemistry\non brain tissue confirmed CAdV-1 infection.\nConclusions: This report discusses possible routes of infection and manifestations of adenovirus infections causing\nneurologic signs. It also provides a timely reminder that CAdV-1 should be considered a differential in unvaccinated\ndogs that present with neurological signs. Further studies are required to better understand the neurotrophic\ntendencies of this virus.
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