Background: The emergence of oral delivery in cancer therapeutics is expected to result in an increased need for\nbetter coordination between all treatment stakeholders, mainly to ensure adequate treatment delivery to the\npatient. There is significant interest in the nurse navigation program�s potential to improve transitions of care by\nimproving communication between treatment stakeholders and by providing personalized organizational\nassistance to patients. The use of health information technology is another strategy aimed at improving cancer\ncare coordination that can be combined with the NN program to improve remote patient follow-up. However,\nthe potential of these two strategies combined to improve oral treatment delivery is limited by a lack of rigorous\nevidence of actual impact.\nMethods/design: We are conducting a large scale randomized controlled trial designed to assess the impact of\na navigation program denoted CAPRI that is based on two Nurse Navigators and a web portal ensuring coordination\nbetween community and hospital as well as between patients and navigators, versus routine delivery of oral anticancer\ntherapy. The primary research aim is to assess the impact of the program on treatment delivery for patients with\nmetastatic cancer, as measured by Relative Dose Intensity. The trial involves a number of other outcomes, including\ntumor response, survival, toxic side effects, patient quality of life and patient experience An economic evaluation\nadopting a societal perspective will be conducted, in order to estimate those health. care resources� used. A parallel\nprocess evaluation will be conducted to describe implementation of the intervention.\nDiscussion: If the CAPRI program does improve treatment delivery, the evidence on its economic impact will offer\nimportant knowledge for health decision-makers, helping develop new follow-up services for patients receiving oral\nchemotherapy and/or targeted therapy. The process evaluation will determine the best conditions in which such a\nprogram might be implemented.
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