The exact cause of breast cancer is unknown; it is a multifactorial disease. It is the most diagnosed and the second killer cancer\namong women. Breast cancer can be originated from tissues of breast or secondary from other organs via metastasis. Generally,\ncancer cells show aberrant metabolism and oxidative stress when compared to noncancerous tissues of breast cancer patients.\nThe current study aims at evaluating glutamate and glucose metabolism through GDH and LDH enzyme activities, oxidant, and\nantioxidative status among breast cancer patients attending referral hospitals of Addis Ababa, Ethiopia. Result. Catalytic\nactivities of glutamate dehydrogenase, lactate dehydrogenase, and oxidative stress index were significantly increased in both\nserum (4.2 mU/ml, 78.6 mU/ml, and 3.3 : 1, resp.) and cancerous tissues (1.4 mU/ml, 111.7 mU/ml, and 2.15 : 1, resp.) of breast\ncancer patients as compared to those in serum of control group (3.15 mU/ml, 30.4 mU/ml, and 2.05 : 1, resp.) and noncancerous\ntissues of breast cancer patients (0.92 mU/ml, 70.5 mU/ml, and 1.1 : 1, resp.) (P � 0 05). Correspondingly, ratios of reduced\nto oxidized glutathione were significantly decreased in both serum (20 : 1) and cancerous tissues (23.5 : 1) of breast cancer\npatients when compared to those in serum of control group (104.5 : 1) and noncancerous tissues of breast cancer patients\n(70.9 : 1) (P � 0 05). Conclusion. Catalytic activities of GDH and LDH, ratios of GSH to GSSG, and concentration of TOS\namong breast cancer patients were significantly higher than were those among control group and noncancerous tissues of\nbreast cancer patients, while TAC of breast cancer patients is significantly lower than that of control group and normal\ntissues of breast cancer patients.
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