Background: Testicular cancer (TC) represents 1% of all new male cancer cases but remains the most frequent cancer\nin adolescents and young adults in industrialized countries. In this study, we assessed time trends in use of sperm\ncryopreservation by men with TC from 1990 to 2013 in France.\nMethods: We collected data from patients diagnosed with TC who underwent sperm cryopreservation in the French\nnational network of sperm banks. Trends in the incidence of sperm cryopreservation were estimated through two\nstatistical models: the commonly used Poisson regression model and the Verhulst model.\nResults: Between 1990 and 2013, the overall incidence of sperm cryopreservation rose from 1.73 to 5.57 per 100,000\nperson-years. Poisson regression predicted an incidence of 9 per 100,000 [95% CI = 8.66â??9.34] in 2020. However, since\n2005, the observed sperm cryopreservation rate seems to be attenuating. The Verhulst model predicted an incidence\nof 6 per 100,000 after 2020.\nConclusions: Limitations include the impossibility of analyzing age-standardized incidence. Based on the Verhulst\nmodel, results suggest that it is still relevant to follow up TC incidence and sperm cryopreservation in order to confirm\nor refute the potential decrease already observed in this disease.
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