Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. PDAC is the fourth leading\ncause of death in the United States and Japan based on epidemiological data. Early detection of\nPDAC is very important to improve the prognosis of PDAC. Early detection of pancreatic ductal\nadenocarcinoma (PDAC) requires further examination after selecting cases with risk factors for the\ncondition, such as family history, hereditary pancreatic carcinoma syndrome, intraductal papillary\nmucinous neoplasms, or chronic pancreatitis. The Japan Study Group on the Early Detection of\nPancreatic Cancer has investigated and clarified the clinicopathological features for the early\ndiagnosis of PDAC. In Japan, an algorithm for the early diagnosis of PDAC, which utilized the\ncooperation of local clinics and regional general hospitals, has been a breakthrough in the detection\nof early-stage PDAC. Further approaches for the early diagnosis of PDAC are warranted.
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