Background: Brain metastasis represents a major complication with a significantly shorter overall survival of many\noncological diseases, in particular of lung cancer, breast cancer and malignant melanoma patients. However,\ndespite the poor prognosis, sometimes clinical decision-making, between on the one hand not to harm the patient\nand on the other hand not withholding a potential therapeutic option, is very challenging. Thus the aim of this\nretrospective study was to compare various scores, including scores for activities of daily living (ADL) before\nresection of brain metastases and to analyse their impact on survival.\nMethods: Our single institution retrospective patient cohort (N = 100) with a median age of 63.6 years, which had\nall undergone resection of one or more brain metastases, was categorized using the original patient files. The\ncohort includes 52 patients with lung cancer, 27 patients with breast cancer, 8 patients with colorectal carcinoma\nand 13 patients with kidney cancer. To categorize, we used different score systems which were capable to evaluate\nthe patient in relation to self-sufficiency, activity and self-determination as part of ADL. The retrospective analysis\nincludes the ECOG-Status, Karnofsky-Index, Barthel-Index, ASA-Classification and Katz-Index. Pre-processing and the\nanalysis of the data was implemented using KNIME, where we used the R-plugin nodes to perform the final\nstatistical tests with R.\nResults: Our analysis reveals that most of the ADL scores we tested are able to give a reliable prediction on overall\nsurvival after brain metastasis surgery. The survival rates decrease significantly with a lower score in all tested score\nsystems, with the exception.........................
Loading....