The aim of the study was to develop extended release matrix tablets of Phenytoin sodium comprising hydrophilic and hydrophobic polymers in different ratios. The matrix tablets were formulated by incorporating combination of Hydroxypropyl methylcellulose K-100 and Ethyl cellulose (7-22 cps) in the concentration range of 2-6%w/w and 6-10%w/w respectively. The optimized formulation was obtained with Hydroxypropyl methyl cellulose (4%w/w) and Ethyl cellulose (8%w/w) in the formulation of matrix tablets. Physical and chemical parameters were evaluated and found within the acceptable limits. In-vitro drug release studies were carried out and mechanism of drug release was predicted using different kinetic models. The optimized formulation showed drug release profile which was within the acceptance criteria specified in USP for Phenytoin sodium extended release dosage forms i.e. less than 30% drug release at 30 mins, 30 - 60 % drug release at 60 mins and more than 60% drug release at the end of 120 mins. Moreover, drug release profiles of all the formulations were compared with the market product and similarity between formulated products and marketed product was determined.
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