Microspheres are well accepted technique to control the drug release from the dosage form to improve bioavailability, reduce absorption difference in patients, reduce the dosing frequency and adverse effects during prolong treatment. The main objective of the present study is to prepare and evaluate glibenclamide microspheres by solvent evaporation method, with water insoluble polymers such as ethyl cellulose, eudragit RS100, cellulose acetate and carboxy methyl cellulose sodium 200-300cps as suspending agent, using as carrier for oral administration in view to achieve oral controlled release of the drug. Glibenclamide is an oral antidiabetic agent which is widely used in the management of non-insulin dependent diabetes mellitus (type II). It is a second generation sulphonyl urea which is more potent than the first generation drugs in this class. Its biological half-life is 4-6 hrs. Due to its low biological half-life (5 hrs), it requires frequent administration to maintain plasma concentration. This causes inconvenience to the patient and also leads fluctuations in plasma drug concentration that may cause inferior therapeutic effects or toxic effects. There-fore, development of controlled release dosage forms would clearly be beneficial in terms of decreased dosage requirements, thus increase patient compliance. Compatibility studies revealed there was no interaction between the drug and polymers. The formulations were evaluated for particle size distribution analysis, flow properties like angle of repose, bulk density, tapped density, hausner’s ratio, carr’s index, encapsulation efficiency, scanning electron microscopy and in-vitro release studies. The optimized formulation showed good in-vitro controlled release activity of the drug glibenclamide.
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