In the present work, an attempt has been made to enhancement solubility and dissolution rate of poorly water soluble drug, naproxen by preparing ternary solid dispersions using combination of two hydrophilic polymers namely PVP K30 and PEG 4000. Drug carrier solid dispersions were prepared by solvent evaporation method using ethanol as a solvent. Solid dispersions of naproxen with PVP K30 and PEG 4000 having ratio of 1:0.5:0.5 markedly increase the solubility and dissolution rate of solid dispersion compared to the free form of naproxen. The characterization of ternary solid dispersion carried out using saturated solubility studies, FTIR spectroscopy, x-ray diffraction and differential scanning calorimetry, in-vitro dissolution study. X-ray diffraction and differential scanning calorimetry resulting the transformation of crystalline to amorphous naproxen. The optimized batch of solid dispersed naproxen formulated into conventional tablet dosage form by applying factorial design. Evaluation of solid dispersed naproxen conventional tablet was performed. In-vitro release of optimized naproxen conventional tablet shows better release as compare to marketed naproxen tablet (Naprosyn®250).
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