Tolnaftate is a topically used antifungal agent, the aim of present research work was to develop an emulgel formulation of tolnaftate. Emulgel have emerged as one of the most interesting topical drug delivery systems as it has dual release control i.e. emulsion and gel. Thus in the present study efforts were made to formulate stable semisolid preparations containing 1% of tolnaftate. On the basis of solubility studies clove oil used as solubiliser of the drug to formulate microemulsion. The ternary diagram was plotted to identify microemulsion region. Various gelling agent were evaluated for their potential to gel of the tolnaftate microemulsion without affecting its structure. The effect of concentration of the gelling agent and emulsifying agent on the drug release was investigated using a 22 factorial design. The prepared emulgel were evaluated for their physical appearance, viscosity, drug release, globule size, spreadability skin irritation test, antifungal activity and stability study. The antifungal activity and drug release were found to be higher for optimized formulation. No irritation was observed on the skin of the white albino mice. Stability studies showed that the physical appearance, rheological study, in-vitro drug release and antifungal activity in all the prepared emulgel remained unchanged upon storage for 1 month.
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