Along with local action of drugs for different purposes such as for the various skin infections, emollients etc and also for cosmetic use topical drug delivery is becoming the area of interest now a days for the systemic delivery of drugs since it is proving to be the alternative for intravenous administration of drugs, due to the advantages like low dose requirement, easy termination of therapy, ease of application. The present review focuses on the details of the skin and its structure with a brief introduction to the barrier properties of the stratum corneum which is an important parameter when topical delivery is under consideration. Also the detail microstructure of the gel formed by different polymers, the method of gel preparation is also discussed.
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