Dissolution testing has emerged in the pharmaceutical field as a very important tool to characterize drug product performance. Dissolution of a drug depends upon solubility of the drug in that medium and therefore solubility becomes the key determinants for oral bioavailability of the drug. Development of dissolution medium for poorly water soluble drug is critical issue. Dissolution problems with poorly soluble compounds generally fall into two categories. Firstly, extent of release is too low, i.e. one cannot get 100% of the dosage form dissolved and Secondly, rate of release is too slow, i.e. one cannot get dissolution fast enough for a convenient test. In the present work an attempt was made to develop dissolution medium for Silymarin The composition of medium was determined on the solubility data of the drug in different media. Saturation solubility of drug was found to be more in phosphate buffer pH 6.8. The effect of surfactants (sodium lauryl sulphate and Tween 80) in different concentration was studied on solubility of drug in phosphate buffer pH 6.8. The study revealed that phosphate buffer pH 6.8 with various concentration of surfactant doesn’t show any significant enhancement of dissolution as compared to plane phosphate buffer pH 6.8. Hence phosphate buffer pH 6.8 was considered to be a most suitable dissolution medium.
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