Granulation may be defined as a size enlargement process which converts small particles into physically stronger & larger agglomerates. This process involves adherence of primary powder particles to form larger, multi particle entities called granules High-shear wet granulation, fluidized-bed granulation, and roller compaction followed by milling are commonly used granulation techniques in the pharmaceutical industry. Primary granule properties of interest are granule size and size distribution, intra granular porosity and granule strength. Bulk properties of interest include bulk density, flowability, and moisture content. Several techniques to observe and control granulation processes are currently being used in the pharmaceutical industry e.g., impeller torque in high-shear mixers. More recently, probes have been used to monitor and control particle size or moisture content of the granulation in high-shear mixers and fluid-bed granulators. Appropriate use of these techniques can provide a more thorough understanding of a formulation and manufacturing process to establish meaningful design space, specifications, and manufacturing controls. Through this review article we are mainly focusing on different method of granulations and innovations in granulation technology.
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