The present study is planned to develop Rosuvastatin calcium into immediate release tablets. Pre-formulation study and drug excipients compatibility study was done initially and the results obtained direct the way and method of formulation. Preformulation and drug excipients compatibility study, prototype formulation carried out for the dose of Rosuvastatin calcium 10 mg and optimized to get the final formula. Rosuvastatin calcium is prone to degradation so compaction and direct compression method is used. All the mentioned batches were taken by the said method. Granules were evaluated for tests such as bulk density, tapped density, compressibility index and Hauser’s ratio and sieve analysis before compression. Tablets were tested for weight variation, thickness, hardness, friability and dissolution. In vitro dissolutions were performed and (F2) values were calculated. Dissolution profile of F8 was matched perfectly with marketed (innovator) formulation and F2 value was found to be excellent. Also the impurity profile and stability result of RF8 was found to be excellent. It can be concluded that the immediate release tablet was effective and stable.
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