After oral administration, the drugs which are better absorbed from stomach suffer from mainly two difficulties: the short gastric retention time and unpredictable short gastric emptying time, which can reduce the bioavailability of administered drug. This drawback has led to the development of oral gastro-retentive dosage forms (GDFs). The gastroretentive dosage form is a type of sustained release dosage form from which the drug is released on continuous basis for a longer period of time as the formulation has enhanced gastric retention period and better bioavailability. Antidiabetic agents of different classes have been proven to be good candidates for the formulation of gastroretentive drug delivery system. The purpose of this paper is to review the literature of the work done on the GDFs of Antidiabetic drugs.
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