In the present study, an attempt was made to formulate sustained release matrix tablets of Lornoxicam using Okra gum as release modifier. Five batches of sustained release matrix tablets of Lornoxicam were prepared by using different drug: polymer ratios. The tablets were analyzed for their hardness, friability, weight variation, and In-vitro release was performed in phosphate buffer saline (PBS) pH 7.4 for nine hours. Swelling study was also carried out to study dispensability of okra gum at different concentrations. The physical characters of the fabricated tablet were within acceptable limits. A better sustained drug release (98.7%) was obtained with the matrix tablet of the Okra gum. Results showed that the drug release from matrix tablets prepared by using natural polymers can be sustained for more than 9 hrs and the drug release vary with concentration of polymer in matrix tablets.
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