The present work is focus to develop and characterize an oral sustained release matrix tablet of Nicardipine Hydrochloride by employing hydrophilic and hydrophilic polymers. Due to poor water solubility of the drug its bioavailability is dissolution rate limited. The purpose of the study was to increase the solubility of Nicardipine Hydrochloride by solvent evaporation technique. Complexes of different molar ratio were prepared. Matrix tablets were prepared by direct compression technique using different concentration of polymers and selected complex. The blended powders and tablets were evaluated for various physico-chemical parameters as per official protocol. The In Vitro dissolution study was carried out in acidic medium (pH 1.2) for 2 h, followed by phosphate buffer dissolution medium (pH 6.8) for next 10 h. The blended powders showed satisfactory flow properties and compressibility. The In Vitro release pattern indicated that formulation F7 releases the drug for period of 12 h and was best fitted to Higuchi release profile. The present study has demonstrated that combination of hydrophobic and hydrophilic polymers effectively sustained the drug release for prolonged period of time12 h.
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